Publications

Perihilar FSGS lesions originate from flat parietal epithelial cells.

Arnaldo Chia-Gil, Jürgen Floege, Eleni Stamellou*,#, and Marcus J. Moeller

J Nephrol. 2024 Feb 1.; doi: 10.1007/s40620-024-01886-y. Online ahead of print.

Sodium-glucose cotransporter 2 inhibition in primary and secondary glomerulonephritis.

Caravaca-Fontán F, Stevens K, Padrón M, Huerta A, Montomoli M, Villa J, González F, Vega C, López Mendoza M, Fernández L, Shabaka A, Rodríguez-Moreno A, Martín-Gómez A, Labrador PJ, Molina Andújar A, Soler MCP, Martín-Penagos L, Yerovi E, Medina Zahonero L, De La Flor JC, Mon C, Ibernon M, Gómez AR, Miquel R, Sierra M, Mascarós V, Luzardo L, Papasotiriou M, Arroyo D, Verdalles Ú, Martínez-Miguel P, Ramírez-Guerrero G, Pampa-Saico S, Moral Berrio E, Canga JLP, Tarragón B, Gómez PF, Regidor D, Relea J, Xipell M, Gómez CA, Navarro M, Álvarez Á, Rivas B, Quintana LF, Gutiérrez E, Pérez-Valdivia MÁ, Odler B, Kronbichler A, Geddes C, Anders HJ, Floege J, Fernández-Juárez G, Praga M; Spanish Group for the Study of Glomerular Diseases (GLOSEN) and the Immunonephrology Working Group of the European Renal Association (ERA)..

Nephrol Dial Transplant. 2023 Aug 7:gfad175. doi: 10.1093/ndt/gfad175. Online ahead of print.

A new alternative: inhibiting complement activation in patients with IgA nephropathy - PubMed (nih.gov)

Floege J.

Kidney Int. 2024.

Detection of PatIent-Level distances from single cell genomics and pathomics data with Optimal Transport (PILOT) - PubMed (nih.gov)

Joodaki, M., Shaigan, M., Parra, V., Roman, D.B., Nagai. J, Mingbo, C., Barratt, J., Roberts, I.S.D., Coppo, R., Kramann, R., Boor, P., Costa, I.G.

bioRxiv [paper | software]., 2022.

Mol Syst Biol., 2024 Feb;20(2):57-74.; doi: 10.1038/s44320-023-00003-8. Epub 2023 Dec 19.

PDGF-D is dispensable for the development and progression of murine Alport syndrome - PubMed (nih.gov)

Firat EAM, Buhl EM, Bouteldja N, Smeets B, Eriksson U, Boor P, Klinkhammer BM.

Am J Pathol. 2024 Feb 1:S0002-9440(24)00036-1.; doi: 10.1016/j.ajpath.2023.12.009. Online ahead of print.

Inhibition of the glucocorticoid receptor attenuates proteinuric kidney diseases in multiple species - PubMed (nih.gov)

Eleni Stamellou, Shipra Agrawal, Florian Siegerist, Christoph Kuppe, Tammo Ostendorf, Tim Lange, Eva Miriam Buhl, Jessica Alam, Thiago Strieder, Peter Boor, Hermann-Josef Gröne, Jürgen Floege, William E. Smoyer, Nicole Endlich and Marcus J. Moeller

Nephrol Dial Transplant., 2023 Nov 30:gfad254. doi: 10.1093/ndt/gfad254. Online ahead of print.

IgA nephropathy

Stamellou, E., Seikrit, C., Tang, S.C.W. et al. IgA nephropathy.

Nat Rev Dis Primers 9, 67 (2023). https://doi.org/10.1038/s41572-023-00476-9

Targeted-release budesonide modifies key pathogenic biomarkers in immunoglobulin A nephropathy: insights from the NEFIGAN trial - PubMed (nih.gov)

Wimbury D, Muto M, Bhachu JS, Scionti K, Brown J, Molyneux K, Seikrit C, Maixnerová D, Pérez-Alós L, Garred P, Floege J, Tesař V, Fellstrom B, Coppo R, Barratt J.

Kidney Int. 2024 Feb;105(2):381-388.; doi: 10.1016/j.kint.2023.11.003. Epub 2023 Nov 25.

3D Printed Tubulointerstitium Chip as an In Vitro Testing Platform - PubMed (nih.gov)

Addario G, Eussen D, Djudjaj S, Boor P, Moroni L, Mota C.

Macromol Biosci. 2023 Nov 23:e2300440.; doi: 10.1002/mabi.202300440. Online ahead of print.

Operational greenhouse-gas emissions of deep learning in digital pathology: a modelling study - PubMed (nih.gov)

Vafaei Sadr A, Bülow R, von Stillfried S, Schmitz NEJ, Pilva P, Hölscher DL, Ha PP, Schweiker M, Boor P.

Lancet Digit Health. 2024 Jan;6(1):e58-e69.; doi: 10.1016/S2589-7500(23)00219-4. Epub 2023 Nov 22.

Inflammation and vascular remodeling in COVID-19 hearts - PubMed (nih.gov)

Werlein C, Ackermann M, Stark H, Shah HR, Tzankov A, Haslbauer JD, von Stillfried S, Bülow RD, El-Armouche A, Kuenzel S, Robertus JL, Reichardt M, Haverich A, Höfer A, Neubert L, Plucinski E, Braubach P, Verleden S, Salditt T, Marx N, Welte T, Bauersachs J, Kreipe HH, Mentzer SJ, Boor P, Black SM, Länger F, Kuehnel M, Jonigk D.

Angiogenesis. 2023 May;26(2):233-248. doi: 10.1007/s10456-022-09860-7. Epub 2022 Nov 12.

CKD therapy to improve outcomes of immune-mediated glomerular diseases.

Anders HJ, Fernandez-Juarez GM, Vaglio A, Romagnani P, Floege J.

Nephrol Dial Transplant. 2023 May 22:gfad069. doi: 10.1093/ndt/gfad069. Online ahead of print.

Ultrasound Localization Microscopy for Breast Cancer Imaging in Patients: Protocol Optimization and Comparison with Shear Wave Elastography - PubMed (nih.gov)

Porte C, Lisson T, Kohlen M, von Maltzahn F, Dencks S, von Stillfried S, Piepenbrock M, Rix A, Dasgupta A, Koczera P, Boor P, Stickeler E, Schmitz G, Kiessling F.

Ultrasound Med Biol. 2024 Jan;50(1):57-66. doi: 10.1016/j.ultrasmedbio.2023.09.001. Epub 2023 Oct 6.

Semiautomated pipeline for quantitative analysis of heart histopathology - PubMed (nih.gov)

Droste P, Wong DWL, Hohl M, von Stillfried S, Klinkhammer BM, Boor P.

J Transl Med. 2023 Sep 26;21(1):666.; doi: 10.1186/s12967-023-04544-2.

Dissecting gene regulation with multimodal sequencing - PubMed (nih.gov)

Costa, I.G.

Nat Methods, 2023 Sep;20(9):1282-1284. doi: 10.1038/s41592-023-01957-1.

A spatially resolved atlas of healthy and injured kidney cell states.

Kuppe C, Kramann R.

Nephrol Dial Transplant. 2023 Sep 14:gfad203. doi: 10.1093/ndt/gfad203. Online ahead of print.

Efficacy and safety of a targeted-release formulation of budesonide in patients with primary IgA nephropathy (NefIgArd): 2-year results from a randomised phase 3 trial.

Lafayette R, Kristensen J, Stone A, Floege J, Tesař V, Trimarchi H, Zhang H, Eren N, Paliege A, Reich HN, Rovin BH, Barratt J

NefIgArd trial investigators. Lancet. 2023 Sep 9;402(10405):859-870.

Novel agents for treating IgA nephropathy.

Kunter U, Seikrit C, Floege J.

Curr Opin Nephrol Hypertens. 2023 Sep 1;32(5):418-426. doi: 10.1097/MNH.0000000000000902. Epub 2023 May 26.

Extending the landscape of omics technologies by pathomics - PubMed (nih.gov)

Bülow, R.D., Hölscher, D.L., Costa, I.G., Boor, P.,

npj Syst Biol Appl. 2023 Aug 7;9(1):38.; doi: 10.1038/s41540-023-00301-9.

2,8-Dihydroxyadenine-induced nephropathy causes hexosylceramide accumulation with increased mTOR signaling, reduced levels of protective SirT3 expression and impaired renal mitochondrial function - PubMed (nih.gov)

Moellmann J, Krueger K, Wong DWL, Klinkhammer BM, Buhl EM, Dehairs J, Swinnen JV, Noels H, Jankowski J, Lebherz C, Boor P, Marx N, Lehrke M.

Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166825. doi: 10.1016/j.bbadis.2023.166825. Epub 2023 Aug 1.

Macrophage migration inhibitory factor (MIF) and its homolog D-dopachrome tautomerase (D-DT) are significant promotors of UVB- but not chemically induced non-melanoma skin cancer - PubMed (nih.gov)

Huth S, Huth L, Heise R, Marquardt Y, Lopopolo L, Piecychna M, Boor P, Fingerle-Rowson G, Kapurniotu A, Yazdi AS, Bucala R, Bernhagen J, Baron JM.

Sci Rep. 2023 Jul 18;13(1):11611. doi: 10.1038/s41598-023-38748-9.

Multi-institutional PET/CT image segmentation using federated deep transformer learning - PubMed (nih.gov)

Shiri I, Razeghi B, Vafaei Sadr A, Amini M, Salimi Y, Ferdowsi S, Boor P, Gündüz D, Voloshynovskiy S, Zaidi H.

Comput Methods Programs Biomed. 2023 Oct;240:107706. doi: 10.1016/j.cmpb.2023.107706. Epub 2023 Jul 12.

Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy - PubMed (nih.gov)

Kiryluk K, Sanchez-Rodriguez E, Zhou XJ, Zanoni F, Liu L, Mladkova N, Khan A, Marasa M, Zhang JY, Balderes O, Sanna-Cherchi S, Bomback AS, Canetta PA, Appel GB, Radhakrishnan J, Trimarchi H, Sprangers B, Cattran DC, Reich H, Pei Y, Ravani P, Galesic K, Maixnerova D, Tesar V, Stengel B, Metzger M, Canaud G, Maillard N, Berthoux F, Berthelot L, Pillebout E, Monteiro R, Nelson R, Wyatt RJ, Smoyer W, Mahan J, Samhar AA, Hidalgo G, Quiroga A, Weng P, Sreedharan R, Selewski D, Davis K, Kallash M, Vasylyeva TL, Rheault M, Chishti A, Ranch D, Wenderfer SE, Samsonov D, Claes DJ, Akchurin O, Goumenos D, Stangou M, Nagy J, Kovacs T, Fiaccadori E, Amoroso A, Barlassina C, Cusi D, Del Vecchio L, Battaglia GG, Bodria M, Boer E, Bono L, Boscutti G, Caridi G, Lugani F, Ghiggeri G, Coppo R, Peruzzi L, Esposito V, Esposito C, Feriozzi S, Polci R, Frasca G, Galliani M, Garozzo M, Mitrotti A, Gesualdo L, Granata S, Zaza G, Londrino F, Magistroni R, Pisani I, Magnano A, Marcantoni C, Messa P, Mignani R, Pani A, Ponticelli C, Roccatello D, Salvadori M, Salvi E, Santoro D, Gembillo G, Savoldi S, Spotti D, Zamboli P, Izzi C, Alberici F, Delbarba E, Florczak M, Krata N, Mucha K, Pączek L, Niemczyk S, Mosz…

Nat Genet. 2023 Jul;55(7):1091-1105. doi: 10.1038/s41588-023-01422-x. Epub 2023 Jun 19.

A meta-analysis of GFR slope as a surrogate endpoint for kidney failure.

Inker LA, Collier W, Greene T, Miao S, Chaudhari J, Appel GB, Badve SV, Caravaca-Fontán F, Del Vecchio L, Floege J, Goicoechea M, Haaland B, Herrington WG, Imai E, Jafar TH, Lewis JB, Li PKT, Maes BD, Neuen BL, Perrone RD, Remuzzi G, Schena FP, Wanner C, Wetzels JFM, Woodward M, Heerspink HJL; CKD-EPI Clinical Trials Consortium.

Nat Med. 2023 Jul;29(7):1867-1876. doi: 10.1038/s41591-023-02418-0. Epub 2023 Jun 17.

Author Correction: A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology - PubMed (nih.gov)

Petersen J, Englmaier L, Artemov AV, Poverennaya I, Mahmoud R, Bouderlique T, Tesarova M, Deviatiiarov R, Szilvásy-Szabó A, Akkuratov EE, Pajuelo Reguera D, Zeberg H, Kaucka M, Kastriti ME, Krivanek J, Radaszkiewicz T, Gömöryová K, Knauth S, Potesil D, Zdrahal Z, Ganji RS, Grabowski A, Buhl ME, Zikmund T, Kavkova M, Axelson H, Lindgren D, Kramann R, Kuppe C, Erdélyi F, Máté Z, Szabó G, Koehne T, Harkany T, Fried K, Kaiser J, Boor P, Fekete C, Rozman J, Kasparek P, Prochazka J, Sedlacek R, Bryja V, Gusev O, Adameyko I.

Nat Commun. 2023 Jun 15;14(1):3565. doi: 10.1038/s41467-023-39373-w.

Transformative Materials to Create 3D Functional Human Tissue Models In Vitro in a Reproducible Manner - PubMed (nih.gov)

Gerardo-Nava JL, Jansen J, Günther D, Klasen L, Thiebes AL, Niessing B, Bergerbit C, Meyer AA, Linkhorst J, Barth M, Akhyari P, Stingl J, Nagel S, Stiehl T, Lampert A, Leube R, Wessling M, Santoro F, Ingebrandt S, Jockenhoevel S, Herrmann A, Fischer H, Wagner W, Schmitt RH, Kiessling F, Kramann R, De Laporte L.

Adv Healthc Mater. 2023 Aug;12(20):e2301030. doi: 10.1002/adhm.202301030. Epub 2023 Jun 13.

Change in Albuminuria and GFR Slope as Joint Surrogate End Points for Kidney Failure: Implications for Phase 2 Clinical Trials in CKD.

Heerspink HJL, Inker LA, Tighiouart H, Collier WH, Haaland B, Luo J, Appel GB, Chan TM, Estacio RO, Fervenza F, Floege J, Imai E, Jafar TH, Lewis JB, Kam-Tao Li P, Locatelli F, Maes BD, Perna A, Perrone RD, Praga M, Schena FP, Wanner C, Xie D, Greene T; on behalf of CKD-EPI CT.

J Am Soc Nephrol. 2023 Jun 1;34(6):955-968. doi: 10.1681/ASN.0000000000000117. Epub 2023 Mar 15.

Role of Surface Curvature in Gold Nanostar Properties and Applications - PubMed (nih.gov)

Xi Z, Zhang R, Kiessling F, Lammers T, Pallares RM.

ACS Biomater Sci Eng. 2024 Jan 8;10(1):38-50. doi: 10.1021/acsbiomaterials.3c00249. Epub 2023 May 30.

IgA nephropathy: the lectin pathway and implications for targeted therapy.

Barratt J, Lafayette RA, Zhang H, Tesar V, Rovin BH, Tumlin JA, Reich HN, Floege J.

Kidney Int. 2023 Aug;104(2):254-264. doi: 10.1016/j.kint.2023.04.029. Epub 2023 May 30.

Sparsentan in patients with IgA nephropathy: a prespecified interim analysis from a randomised, double-blind, active-controlled clinical trial.

Heerspink HJL, Radhakrishnan J, Alpers CE, Barratt J, Bieler S, Diva U, Inrig J, Komers R, Mercer A, Noronha IL, Rheault MN, Rote W, Rovin B, Trachtman H, Trimarchi H, Wong MG, Perkovic V; PROTECT Investigators.

Lancet. 2023 May 13;401(10388):1584-1594. doi: 10.1016/S0140-6736(23)00569-X. Epub 2023 Apr 1.

Biallelic variants in CRIPT cause a Rothmund-Thomson-like syndrome with increased cellular senescence - PubMed (nih.gov)

Averdunk L, Huetzen MA, Moreno-Andrés D, Kalb R, McKee S, Hsieh TC, Seibt A, Schouwink M, Lalani S, Faqeih EA, Brunet T, Boor P, Neveling K, Hoischen A, Hildebrandt B, Graf E, Lu L, Jin W, Schaper J, Omer JA, Demaret T, Fleischer N, Schindler D, Krawitz P, Mayatepek E, Wieczorek D, Wang LL, Antonin W, Jachimowicz RD, von Felbert V, Distelmaier F.

Genet Med. 2023 Jul;25(7):100836. doi: 10.1016/j.gim.2023.100836. Epub 2023 Mar 31.

Bridging the gap between lab and clinic for nanodiagnostics - PubMed (nih.gov)

Pallares RM, Kiessling F, Lammers T.

Nanomedicine (Lond). 2023 Feb;18(5):413-416. doi: 10.2217/nnm-2023-0067. Epub 2023 Mar 28.

International Society of Nephrology first consensus guidance for preclinical animal studies in translational nephrology.

Nangaku M, Kitching AR, Boor P, Fornoni A, Floege J, Coates PT, Himmelfarb J, Lennon R, Anders HJ, Humphreys BD, Caskey FJ, Fogo AB; TRANSFORM group.

Kidney Int. 2023 Jul;104(1):36-45. doi: 10.1016/j.kint.2023.03.007. Epub 2023 Mar 28.

DNA binding protein YB-1 is a part of the neutrophil extracellular trap mediation of kidney damage and cross-organ effects - PubMed (nih.gov)

Jialin Wang , Xiyang Liu, Yulu Gu, Yingying Gao, Vera Jankowski, Nina Was, Anna Leitz, Lucy K Reiss, Yiqin Shi, Jieru Cai, Yi Fang, Nana Song, Shuan Zhao, Jürgen Floege , Tammo Ostendorf, Xiaoqiang Ding and Ute Raffetseder

J. Am. Soc. Nephrol., 2023 Jul; 34:241-257; https://doi.org/10.1681/ASN.2022040491

Taurine as Antioxidant in a Novel Cell- and Oxygen Carrier-Free Perfusate for Normothermic Machine Perfusion of Porcine Kidneys - PubMed (nih.gov)

Zarnitz L, Doorschodt BM, Ernst L, Hosseinnejad A, Edgworth E, Fechter T, Theißen A, Djudjaj S, Boor P, Rossaint R, Tolba RH, Bleilevens C.

Antioxidants (Basel). 2023 Mar 21;12(3):768. doi: 10.3390/antiox12030768.

Magnesium Improves Cardiac Function in Experimental Uremia by Altering Cardiac Elastin Protein Content - PubMed (nih.gov)

Barros X, Friesen X, Mathias Brandenburg V, Liehn EA, Steppan S, Kiessling F, Kramann R, Floege J, Krüger T, Kaesler N.

Nutrients. 2023 Mar 7;15(6):1303. doi: 10.3390/nu15061303.

RGT: a toolbox for the integrative analysis of high throughput regulatory genomics data - PubMed (nih.gov)

Li Z, Kuo CC, Ticconi F, Shaigan M, Gehrmann, J., Gusmao, EG, Allhoff, M., Manolov M., Zenke M., Costa I.G.

[ paper | software] 2023;24(1):79.

BMC Bioinformatics, 2023 Mar 6;24(1):79.; doi: 10.1186/s12859-023-05184-5.

De-novo reconstruction and identification of transcriptional gene regulatory network modules differentiating single-cell clusters - PubMed (nih.gov)

Mhaned Oubounyt, Maria L. Elkjaer, Tanja Laske, Alexander G.B. Grønning, Marcus J. Moeller, and Jan Baumbach

NAR Genom Bioinform., 2023 Mar 3;5(1):lqad018.; doi: 10.1093/nargab/lqad018. eCollection 2023 Mar.

Prediction of heart transplant rejection from routine pathology slides with self-supervised deep learning - PubMed (nih.gov)

Seraphin TP, Luedde M, Roderburg C, van Treeck M, Scheider P, Buelow RD, Boor P, Loosen SH, Provaznik Z, Mendelsohn D, Berisha F, Magnussen C, Westermann D, Luedde T, Brochhausen C, Sossalla S, Kather JN.

Eur Heart J Digit Health. 2023 Mar 2;4(3):265-274. doi: 10.1093/ehjdh/ztad016. eCollection 2023 May.

Platelet-instructed SPP1+ macrophages drive myofibroblast activation in fibrosis in a CXCL4-dependent manner - PubMed (nih.gov)

Hoeft K, Schaefer GJL, Kim H, Schumacher D, Bleckwehl T, Long Q, Klinkhammer BM, Peisker F, Koch L, Nagai J, Halder M, Ziegler S, Liehn E, Kuppe C, Kranz J, Menzel S, Costa I, Wahida A, Boor P, Schneider RK, Hayat S, Kramann R.

Cell Rep. 2023 Feb 28;42(2):112131. doi: 10.1016/j.celrep.2023.112131. Epub 2023 Feb 18.

Reduction of Endothelial Glycocalyx on Peritubular Capillaries in Chronic Kidney Disease - PubMed (nih.gov)

Ermert K, Buhl EM, Klinkhammer BM, Floege J, Boor P.

Am J Pathol. 2023 Feb;193(2):138-147. doi: 10.1016/j.ajpath.2022.11.003. Epub 2022 Nov 19.

Platelet-instructed SPP1+ macrophages drive myofibroblast activation in fibrosis in a CXCL4-dependent manner.

Cell Rep. 2023 Feb 28;42(2):112131. doi: 10.1016/j.celrep.2023.112131. Epub 2023 Feb 18.

The Role of Platelet-Derived Growth Factor in Focal Segmental Glomerulosclerosis - PubMed (nih.gov)

Ting Jia , Tong Xu , Bart Smeets, Eva Miriam Buhl, Marcus J Moeller, Jürgen Floege, Barbara M Klinkhammer and Peter Boor

NAR Genom Bioinform. 2023 Feb 1; 5:lqad018; https://doi.org/10.1093/nargab/lqad018

Next-Generation Morphometry for pathomics-data mining in histopathology - PubMed (nih.gov)

Hölscher, D.L., Bouteldja, N., Joodaki, M., Russo, M.L., Lan, Y.-C., Sadr, A.V., Cheng, M., Tesar, V., Stillfried, S. V., Klinkhammer, B.M., Barratt, J., Floege, J., Roberts, I.S.D., Coppo, R., Costa, I.G., Bülow, R.D., Boor, P.

Nat. Commun., 2023 Jan 28;14(1):470.; doi: 10.1038/s41467-023-36173-0.

Stain-Independent Deep Learning-Based Analysis of Digital Kidney Histopathology - PubMed (nih.gov)

Bouteldja N, Hölscher DL, Klinkhammer BM, Buelow RD, Lotz J, Weiss N, Daniel C, Amann K, Boor P.

Am J Pathol. 2023 Jan;193(1):73-83. doi: 10.1016/j.ajpath.2022.09.011. Epub 2022 Oct 26.

scMEGA: single-cell multi-omic enhancer-based gene regulatory network inference.

Li Z, Nagai JS, Kuppe C, Kramann R, Costa IG.

Bioinform Adv. 2023 Jan 12;3(1):vbad003. doi: 10.1093/bioadv/vbad003. eCollection 2023.

Coagulation-independent effects of thrombin and Factor Xa: role of protease-activated receptors in pulmonary hypertension - PubMed (nih.gov)

Joseph C, Berghausen EM, Behringer A, Rauch B, Ten Freyhaus H, Gnatzy-Feik LL, Krause M, Wong DWL, Boor P, Baldus S, Vantler M, Rosenkranz S.

Cardiovasc Res. 2022 Dec 29;118(16):3225-3238. doi: 10.1093/cvr/cvac004.

Adversarial attacks and adversarial robustness in computational pathology - PubMed (nih.gov)

Ghaffari Laleh N, Truhn D, Veldhuizen GP, Han T, van Treeck M, Buelow RD, Langer R, Dislich B, Boor P, Schulz V, Kather JN.

Nat Commun. 2022 Sep 29;13(1):5711. doi: 10.1038/s41467-022-33266-0.

Renal inflamm-aging provokes intra-graft inflammation following experimental kidney transplantation - PubMed (nih.gov)

He A, Sarwar A, Thole LML, Siegle J, Sattler A, Ashraf MI, Proß V, Stahl C, Dornieden T, Bergmann Y, Ritschl PV, Ebner S, Hublitz KW, Stamatiades EG, Bülow RD, Boor P, Kotsch K.

Am J Transplant. 2022 Nov;22(11):2529-2547. doi: 10.1111/ajt.17154. Epub 2022 Jul 30.

Genetic regulation of serum IgA levels and susceptibility to common immune,

infectious, kidney, and cardio-metabolic traits

Liu L, Khan A, Sanchez Rodriguez E, Zanoni F, Li Y , Steers N, Balderes O, Zhang J, Krithivasan P, LeDesma RA,

Fischman C, Hebbring SJ, Harley JB, Moncrieffe H, Kottyan LC, Namjou Khales B, Walunas TL, Knevel R, Raychaudhuri S, Karlson EW, Denny JC, Stanaway IB, Crosslin D, Rauen T, Floege J, Eitner F, Moldoveanu Z, Reily C, Knoppova B, Hall S, Sheff JT, Julian BA, Wyatt RJ, Suzuki H, Xie J, Chen N, Zhou X, Zhang H, Hammarström L, Viktorin A, Magnusson PKE, Shang N, Hripcsak G, Weng C, Rundek T, Elkind MS, Oelsner EC, Barr RG, Ionita-Laza J, Novak J, Gharavi AG, Kiryluk K

Nat Commun. 2022 Nov 11;13(1):6859. doi: 10.1038/s41467-022-34456-6.

Adult human kidney organoids originate from CD24+ cells and represent an advanced model for adult polycystic kidney disease - PubMed (nih.gov)

Xu Y, Kuppe C, Perales-Patón J, Hayat S, Kranz J, Abdallah AT, Nagai J, Li Z, Peisker F, Saritas T, Halder M, Menzel S, Hoeft K, Kenter A, Kim H, van Roeyen CRC, Lehrke M, Moellmann J, Speer T, Buhl EM, Hoogenboezem R, Boor P, Jansen J, Knopp C, Kurth I, Smeets B, Bindels E, Reinders MEJ, Baan C, Gribnau J, Hoorn EJ, Steffens J, Huber TB, Costa I, Floege J, Schneider RK, Saez-Rodriguez J, Freedman BS, Kramann R.

Nat Genet. 2022 Nov;54(11):1690-1701. doi: 10.1038/s41588-022-01202-z. Epub 2022 Oct 27.

Pro-oxidative priming but maintained cardiac function in a broad spectrum of murine models of chronic kidney disease - PubMed (nih.gov)

Wollenhaupt J, Frisch J, Harlacher E, Wong DWL, Jin H, Schulte C, Vondenhoff S, Moellmann J, Klinkhammer BM, Zhang L, Baleanu-Curaj A, Liehn EA, Speer T, Kazakov A, Werner C, van der Vorst EPC, Selejan SR, Hohl M, Böhm M, Kramann R, Biessen EAL, Lehrke M, Marx N, Jankowski J, Maack C, Boor P, Prates Roma L, Noels H.

Redox Biol. 2022 Oct;56:102459. doi: 10.1016/j.redox.2022.102459. Epub 2022 Aug 30.

Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing - PubMed (nih.gov)

Kessler N, Viehmann SF, Krollmann C, Mai K, Kirschner KM, Luksch H, Kotagiri P, Böhner AMC, Huugen D, de Oliveira Mann CC, Otten S, Weiss SAI, Zillinger T, Dobrikova K, Jenne DE, Behrendt R, Ablasser A, Bartok E, Hartmann G, Hopfner KP, Lyons PA, Boor P, Rösen-Wolff A, Teichmann LL, Heeringa P, Kurts C, Garbi N.

J Exp Med. 2022 Oct 3;219(10):e20220759. doi: 10.1084/jem.20220759. Epub 2022 Aug 23.

TESTING the effects of corticosteroids in patients with IgA nephropathy

Seikrit C, Stamellou E, Rauen T, Floege J

Nephrol Dial Transplant. 2022 Jul 26;gfac221. doi: 10.1093/ndt/gfac221. Online ahead of print.

Intestinal permeability in patients with IgA nephropathy and other glomerular diseases: an observational study - PubMed (nih.gov)

Seikrit C, Schimpf JI, Wied S, Stamellou E, Izcue A, Pabst O, Rauen T, Lenaerts K, Floege J.

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Current kidney function parameters overestimate kidney tissue repair in reversible experimental kidney disease

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