Understanding and monitoring renal microvascular remodeling in CKD by super-resolution ultrasound
Pathological microvascular remodeling and microvascular dysfunction are common findings and contributing factors in progressive CKD, but in-vivo imaging methods that allow for their quantification are not available. Recently, we developed a super-resolution ultrasound method, enabling a highly detailed microvascular characterization of tissues at the morphologic and functional level.
We here aim to develop super-resolution ultrasound for experimental and clinical nephrology to analyze microvascular alterations in kidney diseases. Our aims are to (i) establish super-resolution ultrasound imaging in mice and humans and ii) investigate renal microvascular remodeling during the transition from AKI to CKD including the role of macrophage migration inhibitory factor (MIF). Furthermore, using super-resolution ultrasound and radiomic analyses, we will perform a first clinical trial with patients with different stages of CKD.
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